[Correlation of 1p/16q loss of heterozygosity and 1p gain with clinicopathological characteristics and prognosis in Wilms tumor].

Objective: To investigate the relationship between 1p/16q loss of heterozygosity (LOH) and 1p gain in Wilms tumor and their clinicopathologic characteristics and prognosis. Methods: A total of 175 Wilms tumor samples received from the Department of Pathology, Beijing Children's Hospital from September 2019 to August 2022 were retrospectively analyzed. The histopathologic type and presence of lymph node involvement were evaluated by two pathologists. The clinical data including patients'gender, age, tumor location, preoperative chemotherapy, and tumor stage were summarized. Fluorescence in situ hybridization (FISH) was done to detect 1p/16q LOH and 1p gain and their correlation with the clinicopathological features and prognosis were analyzed. Results: Among the 175 samples, 86 cases (49.1%) were male and 89 (50.9%) were female. The mean age was (3.5±2.9) years, and the median age was 2.6 years. There were 26 (14.9%) cases with 1p LOH, 28 (16.0%) cases with 16q LOH, 10 (5.7%) cases of LOH at both 1p and 16q, and 53 (30.3%) cases with 1q gain. 1q gain was significantly associated with 1p LOH (P<0.01) and 16q LOH (P<0.01). There were significant differences (P<0.01) between 1q gain, 1p LOH and 16q LOH among different age groups. The rate of 16q LOH in the high-risk histopathological subtype (50.0%) was significantly higher than that in the intermediate-risk subtype (13.6%, P<0.05). The frequency of 1q gain, 1p LOH, and 16q LOH in children with advanced clinical stages (Ⅲ and Ⅳ) was significantly higher than that in children with early clinical stages (Ⅰ and Ⅱ). 1q gain, 1p LOH, and 16q LOH showed no significant correlation with gender, unilateral or bilateral disease, chemotherapy, or lymph node metastasis. The progression-free survival (PFS) time for patients with 1q gain and 1p LOH was significantly shorter than those without these aberrations (P<0.05). Additionally, the PFS time of patients with 16q LOH was slightly shorter than those with normal 16q, although the difference was not statistically significant. Patients with stage Ⅲ to Ⅳ disease exhibiting 1q gain or 1p LOH had a significantly higher relative risk of recurrence, metastasis, and mortality. Conclusions: 1p/16q LOH and 1q gain are associated with age, high-risk histological type, and clinical stage in Wilms tumor. 1q gain and 1p LOH are significantly correlated with the prognosis of Wilms tumor.

[Association of hs-CRP with frailty and its components among the elderly over 65 years old in 9 longevity areas of China].

Objective: To investigate the association of the levels of high sensitivity C-reactive protein (hs-CRP) with frailty and its components among the elderly over 65 years old in 9 longevity areas of China. Methods: Cross-sectional data from the Health Ageing and Biomarkers Cohort Study (HABCS, 2017-2018) were used and the elderly over 65 years old were included in this study. Through questionnaire interview and physical examination, the information including demographic characteristics, behavior, diet, daily activity, cognitive function, and health status was collected. The association between hs-CRP and frailty and its components in the participants was analyzed by multivariate logistic regression model and restrictive cubic spline. Results: A total of 2 453 participants were finally included, the age was (84.8±19.8) years old. The median hs-CRP level was 1.13 mg/L and the prevalence of frailty was 24.4%. Compared with the low-level group (hs-CRP<1.0 mg/L), the OR (95%CI) value of the high-level group (hs-CRP>3.0 mg/L) was 1.79 (1.35-2.36) mg/L. As for the components, the hs-CRP level was also positively associated with ADL disability, IADL disability, functional limitation and multimorbidity. After adjusting for confounding factors, compared with the low-level group, the OR (95%CI) values of the high-level group for the four components were 1.68 (1.25-2.27), 1.88 (1.42-2.50), 1.68 (1.31-2.14) and 1.39 (1.12-1.72), respectively. Conclusion: There is a positive association between the levels of hs-CRP and the risk of frailty among the elderly over 65 years old in 9 longevity areas of China. The higher hs-CRP level may increase the risk of frailty by elevating the risk of four physical functional disabilities, namely ADL disability, IADL disability, functional limitation and multimorbidity.

[Association between urinary arsenic level and serum testosterone in Chinese men aged 18 to 79 years].

Objective: To investigate the association between the urinary arsenic level and serum total testosterone in Chinese men aged 18 to 79 years. Methods: A total of 5 048 male participants aged 18 to 79 years were recruited from the China National Human Biomonitoring (CNHBM) from 2017 to 2018. Questionnaires and physical examinations were used to collect information on demographic characteristics, lifestyle, food intake frequency and health status. Venous blood and urine samples were collected to detect the level of serum total testosterone, urinary arsenic and urinary creatinine. Participants were divided into three groups (low, middle, and high) based on the tertiles of creatinine-adjusted urinary arsenic concentration. Weighted multiple linear regression was fitted to analyze the association of urinary arsenic with serum total testosterone. Results: The weighted average age of 5 048 Chinese men was (46.72±0.40) years. Geometric mean concentration (95%CI) of urinary arsenic, creatinine-adjusted urinary arsenic and serum testosterone was 22.46 (20.08, 25.12) µg/L, 19.36 (16.92, 22.15) µg/g·Cr and 18.13 (17.42, 18.85) nmol/L, respectively. After controlling for covariates, compared with the low-level urinary arsenic group, the testosterone level of the participants in the middle-level group and the high-level group decreased gradually. The percentile ratio (95%CI) was -5.17% (-13.14%, 3.54%) and -10.33% (-15.68%, -4.63). The subgroup analysis showed that the association between the urinary arsenic level and testosterone level was more obvious in the group with BMI<24 kg/m2 group (Pinteraction=0.023). Conclusion: There is a negative association between the urinary arsenic level and serum total testosterone in Chinese men aged 18 to 79 years.

[Mediation effect of inflammatory biomarkers on the association between blood lead levels and blood pressure changes in Chinese adults].

Objective: To investigate the role of inflammatory biomarkers in the relationship between blood lead levels and blood pressure changes. Methods: A total of 9 910 people aged 18-79 years who participated in the China National Human Biomonitoring in 2017-2018 were included in this study. A self-made questionnaire was used to collect demographic characteristics, lifestyle and other information, and the data including height, weight and blood pressure were determined through physical examination. Blood and urinary samples were collected for the detection of blood lead and cadmium levels, urinary arsenic levels, white blood cells, neutrophils, lymphocytes, and hypersensitive C-reactive protein (hs-CRP). Weighted linear regression models were used to evaluate the associations between blood lead, inflammatory biomarkers and blood pressure. Mediation analysis was performed to investigate the role of inflammation in the relationship between blood lead levels and blood pressure changes. Results: The median (Q1, Q3) age of all participants was 45.4 (33.8, 58.4)years, including 4 984 males accounting for 50.3%. Multivariate logistic regression model analysis showed that after adjusting for age, gender, residence area, BMI, education level, smoking and drinking status, family history of hypertension, consumption frequency of rice, vegetables, and red meat, fasting blood glucose, total cholesterol, triglycerides, blood cadmium and urinary arsenic levels, there was a positive association between blood lead levels, inflammatory biomarkers and blood pressure (P<0.05). Each 2.71 µg/L (log-transformed) increase of the lead was associated with a 2.05 (95%CI: 0.58, 3.53) mmHg elevation in systolic blood pressure (SBP), 2.24 (95%CI: 1.34, 3.14) mmHg elevation in diastolic blood pressure (DBP), 0.25 (95%CI: 0.05, 0.46) mg/L elevation in hs-CRP, 0.16 (95%CI: 0.03, 0.29)×109/L elevation in white blood cells, and 0.11 (95%CI: 0.02, 0.21)×109/L elevation in lymphocytes, respectively. Mediation analysis showed that the levels of hs-CRP significantly mediated the association of blood lead with SBP, with a proportion about 3.88% (95%CI: 0.45%, 7.32%). The analysis also found that the levels of hs-CRP and neutrophils significantly mediated the association of blood lead with SBP, with a proportion about 4.10% (95%CI: 1.11%, 7.10%) and 2.42% (95%CI: 0.07%, 4.76%), respectively. Conclusion: This study suggests that inflammatory biomarkers could significantly mediate the association of blood lead levels and blood pressure changes.

[Association of lead exposure with stunting and underweight among children aged 3-5 years in China].

Objective: To evaluate the association of lead exposure with stunting and underweight among children aged 3-5 years in China. Methods: Data was collected from China National Human Biomonitoring (CNHBM) between January 2017 and December 2018. A total of 3 554 children aged 3-5 years were included. Demographic characteristic, lifestyle and nutritional status were collected through questionnaires. Height and weight were measured by standardized method. Stunting and underweight status were determined by calculating height for age Z-score and weight for age Z-score. Blood and urine samples were collected to detect the concentrations of blood lead, urinary lead and urinary creatinine. Children were stratified into 4 groups (Q1 to Q4) by quartiles of blood lead level and corrected urinary lead level, respectively. Complex sampling logistic regression models were applied to evaluate the association of the blood lead level, urinary lead level with stunting and underweight. Results: Among 3 554 children, the age was (4.09±1.06) years, of which 1 779 (80.64%) were female and 1 948 (55.84%) were urban residents. The prevalence of stunting and wasting was 7.34% and 2.96%, respectively. The M (Q1, Q3) for blood lead levels and urinary lead levels in children was 17.49 (12.80, 24.71) µg/L, 1.20 (0.61, 2.14) µg/g Cr, respectively. After adjusting for confounding factors, compared with the lowest blood lead concentration group Q1, the risk of stunting gradually increased in the Q3 and Q4 group (Ptrend=0.010), with OR (95%CI) values of 1.40 (0.80-2.46) and 1.80 (1.07-3.04), respectively. Compared with the lowest urinary lead concentration group Q1, the risk of stunting still increased in the Q3 and Q4 group (Ptrend=0.012), with OR (95%CI) values of 1.69 (1.01-2.84) and 1.79 (1.05-3.06), respectively. The correlation between the lead exposure and underweight was not statistically significant (P>0.05). Conclusion: Lead exposure is positively associated with the risk of stunting among children aged 3-5 years in China.

[Effect of topical glucocorticoid in treating phimosis on urinary tract infection of vesicoureteral reflux in infants].

Objective: To evaluate the effect of topical glucocorticoid in treating phimosis on urinarytract infection(UTI) of vesicoureteral reflux(VUR) in infants. Methods: Clinical data of infants with UTI diagnosed as primary VUR admitted to our hospital from January 2016 to January 2021 were retrospectively analyzed. The children were divided into three groups:the effective group (topical glucocorticoid was effective in the treatment of phimosis), the ineffective group(topical glucocorticoid was ineffective in the treatment of phimosis), and the untreated group(phimosis was not treated). Age of onset, degree of reflux, side and other indicators were compared to understand the effectiveness of topical glucocorticoid in treating phimosis, and the clinical characteristics of repeated UTI with VUR in treated phimosis and untreated phimosis. Results: A total of 544 children were included. Among them, 59 cases were treated with topical glucocorticoid for phimosis, 48 cases in the effective group, and their age was (12.5±8.4) months;11 cases in the ineffective group,and their age was (11.2±8.9) months. There were 485 cases in the untreated group, and their age was (13.1±9.3) months.The effective rate of topical glucocorticoid in the treatment of phimosis was 81.36%. There were 12 cases(12/48) of recurrent UTI in the effective group and 213 cases (213/485)of recurrent UTI in the untreated group, and the difference between the two groups was statistically significant (P=0.008). Conclusion: Treatment of phimosis with topical glucocorticoid is an effective, easy to perform, and cost-effective method, and can effectively reduce the risk of recurrent UTI in infants with primary VUR.

An overview of array invariant for source-range estimation in shallow water.

Traditional matched-field processing (MFP) refers to array processing algorithms, which fully exploit the physics of wave propagation to localize underwater acoustic sources. As a generalization of plane wave beamforming, the "steering vectors," or replicas, are solutions of the wave equation descriptive of the ocean environment. Thus, model-based MFP is inherently sensitive to environmental mismatch, motivating the development of robust methods. One such method is the array invariant (AI), which instead exploits the dispersion characteristics of broadband signals in acoustic waveguides, summarized by a single parameter known as the waveguide invariant ß. AI employs conventional plane wave beamforming and utilizes coherent multipath arrivals (eigenrays) separated into beam angle and travel time for source-range estimation. Although originating from the ideal waveguide, it is applicable to many realistic shallow-water environments wherein the dispersion characteristics are similar to those in ideal waveguides. First introduced in 2006 and denoted by χ, the dispersion-based AI has been fully integrated with ß. The remarkable performance and robustness of AI were demonstrated using various experimental data collected in shallow water, including sources of opportunity. Further, it was extended successfully to a range-dependent coastal environment with a sloping bottom, using an iterative approach and a small-aperture array. This paper provides an overview of AI, covering its basic physics and connection with ß, comparison between MFP and AI, self-calibration of the array tilt, and recent developments such as adaptive AI, which can handle the dependence of ß on the propagation angle, including steep-angle arrivals.

The waveguide invariant for a Pekeris waveguide.

A closed-form waveguide invariant ß for a Pekeris waveguide is derived. It is based on the modal Wentzel-Kramers-Brillouin (WKB) dispersion equation and implicit differentiation, in conjunction with the concept of the "effective boundary depth," ΔH(θ), where θ is the propagation angle. First, an explicit formula for ß(m,n) between mode pairs is obtained assuming an ideal waveguide of the effective waveguide depth, H+ΔH(θ), and provides an excellent agreement with the reference value for the Pekeris waveguide of depth H obtained using the normal mode program kraken. Then, a closed-form expression for a group of adjacent modes is derived: ß=(H+ΔH(θ))/(H/ cos2 θ-ΔH(θ)), which can be approximated by ß=cos2 θ as ΔH(θ)/H≪1, the analytical expression for an ideal waveguide.

[Association of blood lead and blood selenium with serum high-sensitivity C-reactive protein among Chinese adults aged 19 to 79 years].

Objective: To investigate the association of blood lead and blood selenium with serum high-sensitivity C-reactive protein (hs-CRP) among Chinese adults aged 19 to 79 years. Methods: The participants were enrolled from the first wave of China National Human Biomonitoring (CNHBM) conducted from 2017 to 2018. 10 153 participants aged 19 to 79 years were included in this study. Fasting blood samples were obtained from participants. Lead and selenium in whole blood and hs-CRP in serum were measured. Individuals with hs-CRP levels above 3.0 mg/L were defined as elevated hs-CRP. Generalized linear mixed models and restricted cubic spline models were used to analyze the association of blood lead and blood selenium with elevated hs-CRP. Logistic regression models were used to analyze the multiplicative scale and additive scale interaction between blood lead and blood selenium on elevated hs-CRP. Results: The age of participants was (48.91±15.38) years, of which 5 054 (61.47%) were male. 1 181 (11.29%) participants were defined as elevated hs-CRP. After multivariable adjustment, results from generalized linear models showed that compared with participants with the lowest quartile of blood lead, the OR (95%CI) of elevated hs-CRP for participants with the second, third, and highest quartiles were 1.14 (0.94-1.37), 1.25 (1.04-1.52) and 1.38 (1.13-1.68), respectively. When compared with participants with the lowest quartile of blood selenium, the OR (95%CI) of elevated hs-CRP for participants with the second, third and highest quartiles were 0.86 (0.72-1.04), 0.91 (0.76-1.11), and 0.75 (0.61-0.92), respectively. Results from the interaction analysis showed no significant interaction between lead and selenium on elevated hs-CRP. Conclusion: Blood concentration of lead was positively associated with elevated serum hs-CRP, and blood concentration of selenium was inversely related to elevated hs-CRP, while blood lead and selenium did not present interaction on elevated hs-CRP.

[Association of cadmium internal exposure with chronic kidney disease in Chinese adults].

Objective: To analyze the association of the cadmium internal exposure with chronic kidney disease (CKD) in Chinese adults aged 18 and older. Methods: A total of 9 821 adults aged 18-79 from the China National Human Biomonitoring (CNHBM) from 2017 to 2018 were included. Blood and urine cadmium exposure levels were measured by inductively coupled plasma mass spectrometry (ICP-MS), and urine cadmium levels were adjusted with urine creatinine; CKD were defined by estimated glomerular filtration (eGFR) using the chronic kidney disease epidemiology collaboration (CKD-EPI). Weights were considered due to complex sampling process for in statistical analysis. Logistic regression is used to analyze the association of blood cadmium, urine cadmium, and urine cadmium adjusted with creatinine exposure levels with CKD, and restricted cube spline (RCS) was used to assess the exposure-response curve of blood cadmium, urine cadmium and urine cadmium adjusted with creatinine with CKD. Results: The weighted age was 44.75 and males accounted for 61.1%. The prevalence rate of CKD was 12.7%. The geometric mean values of blood cadmium, urine cadmium, and urine cadmium adjusted with creatinine were 0.96 µg/L, 0.61 µg/L, and 0.58 µg/g. After adjusting for confounding factors, the weighted logistic regression showed that the lowest quintile (Q1) was compared with the odds ratio (OR) of the highest quintile (Q5) of blood cadmium, urine cadmium, and urine cadmium adjusted with creatinine and the 95% confidence interval (CI) was 1.80 (1.02-3.20), 1.77 (0.94-3.31) and 1.94 (1.11-3.37) respectively. In the restricted cubic spline regression model, non-linear association of blood cadmium, urine cadmium, and urine cadmium adjusted with creatinine with CKD were observed after adjusting for related confounding factors (P<0.001, 0.018, 0.031 respectively). The risk of CKD increased with the increment of cadmium exposure without risk threshold, and the exposure response curve was steeper at low cadmium exposure. Conclusions: Among Chinese adults aged 18 and older, cadmium exposure is positively associated with the risk of chronic kidney disease.

Localization of a distant ship using a guide ship and a vertical array.

A method is presented for estimating the range of a distant ship in shallow water using a vertical array and a guide ship at a known range close to the array. The method involves a combination of four different approaches: blind deconvolution, waveguide invariant, virtual receiver (VR), and array invariant. (1) Blind deconvolution extracts a time-domain Green's function from the broadband acoustic source (guide ship). (2) The Green's function is extrapolated into adjacent ranges using the waveguide invariant, generating a horizontal array of synthetic guide sources. (3) Each guide source then turns into a VR where the output approximates the signal that the distant (objective) ship will produce at the location of the guide source. (4) The horizontal virtual array around the guide ship applies the blind deconvolution again to estimate the Green's function for the objective source, followed by the array invariant to estimate the distance between the two ships. The proposed method is demonstrated using a ship of opportunity radiating broadband noise (100-500 Hz) and a 56.25-m long vertical array in approximately 100-m water.

[A cohort study on plasma uric acid levels and the risk of type 2 diabetes mellitus among the oldest old in longevity areas of China].

Objective: To investigate the effect of plasma uric acid level on the incident risk of type 2 diabetes mellitus (T2DM) among the oldest old (those aged ≥80 years). Methods: Participants were recruited from the Healthy Aging and Biomarkers Cohort Study (HABCS), which conducted a baseline survey in 2008-2009 and follow-up of 3 times in 2011-2012, 2014, and 2017-2018, respectively. A total of 2 213 oldest old were enrolled in this study. The general demographic, socioeconomic, lifestyle and disease data of the oldest old were collected, and physical measurements were made for the oldest old. Fasting venous blood was collected for uric acid and blood glucose detection. Information on the incident and death of T2DM were collected through the follow-up. Cox proportional hazard regression model was used to explore the association of hyperuricemia and plasma uric acid level with the incidence of T2DM. Restricted cubic spline (RCS) function was used to explore the dose-response relationship of plasma uric acid levels with the risk of T2DM. Results: The age of participants was (93.2±7.6) years old, and 66.7% of the participants (1 475) were female. The plasma uric acid level at baseline was (289.1±88.0)µmol/L, and the prevalence of hyperuricemia was 13.3% (294 cases). During 9 years of cumulative follow-up of 7 471 person-years (average of 3.38 years for each), 122 new cases of T2DM occurred and the incidence density was 1 632.98/105 person year. Cox proportional hazards regression analysis showed that per 10µmol/L increase in plasma uric acid level, the risk of T2DM increased by 1.1% [HR (95%CI): 1.011 (1.004, 1.017)]. Compared with the participants with the lowest quintile of plasma uric acid (Q1), the risk of diabetes increased by 20.7 % among the oldest old with uric acid in the highest quintile (Q5) [HR (95%CI):1.207 (1.029, 1.416)]. The risk of T2DM was 19.2% higher in the hyperuricemia group than that in the oldest old with normal plasma uric acid [HR (95%CI): 1.192 (1.033, 1.377)]. RCS function showed that the risk of T2DM increased with the increase in plasma uric acid levels in a nonlinear dose-response relationship (P=0.016). Conclusion: The incident risk of T2DM increases with the elevates of plasma uric acid levels in the oldest old.

Adaptive array invariant in range-dependent environments with variable bathymetry.

The adaptive array invariant developed for source-range estimation in shallow water can incorporate the propagation-angle dependence of the waveguide invariant for an ideal waveguide (ß=cos2θ) [Byun and Song, J. Acoust. Soc. Am. 148, 925-933 (2020)]. This paper extends the approach to weakly (adiabatic) range-dependent environments with variable bathymetry, wherein the waveguide invariant is a complex function of the bathymetry between source and receiver as well as the propagation angle in powers of sin2θ. For a given bathymetry, the adaptive array invariant can be implemented in an iterative fashion, and its remarkable performance is demonstrated using a short-aperture vertical array (2.8 m) for a broadband source (0.5-3.5 kHz) towed on a continental slope where the water depth varies from 87.5 to 55 m over a 5-km range.

Observations of scatter from surface reflectors with Doppler sensitive probe signals.

Previous analyses of surface scatter from the at-sea KAM11 experiment were made with linear frequency modulated waveforms that emphasized a single slope direction for arrivals in time-varying impulse response estimates. This analysis of Doppler sensitive waveform transmissions, made in the same geometry, resolves additional scatter arrivals with opposite slope. The different Doppler shifts in scatter observations are related to dispersed, naturally occurring, sea surface features that reflect the transmitted waveform to the receiver. The positions of these surface reflectors are estimated from the delay and Doppler shift of the observed arrivals without needing a receiving array with high spatial resolution.

Extracting Green's functions between ships of opportunity using a vertical array.

A theoretical method for estimating the Green's function between two points in an acoustic waveguide was proposed using a vertical source array that spans sufficient waveguide depth [Roux and Fink, J. Acoust. Soc. Am. 113, 1406-1416 (2003)]. This paper shows that by reversing the role of sources and receivers, the Green's function between two ships (sources) can be extracted using a vertical receiver array with a limited aperture. First, the Green's functions from each ship are estimated along the array via blind deconvolution. Then the Green's function between two ships is obtained by either correlation or convolution of the individual Green's functions summed over the array, depending on the array position with respect to the ships. The feasibility of extracting Green's functions between ships of opportunity radiating random broadband (100-500 Hz) noise is demonstrated using a 56.25-m aperture vertical array in approximately 100-m shallow water.

Adaptive array invariant.

The array invariant (χ) developed for robust source-range estimation in shallow water is based on the broadband dispersion characteristics in ideal waveguides that can be summarized by the waveguide invariant, ß=cos2θ, with propagation angle θ. The standard array invariant relies on the waveguide invariant being constant, e.g., ß = 1, valid for small propagation angles (θ<20°). In this paper, the array invariant is extended to fully incorporate the angle dependence of the waveguide invariant (ß=cos2θ), referred to as adaptive array invariant and denoted by χß=χ/ß, which, in theory, provides a perfect range estimate without constraining the propagation angle. The superior performance of the adaptive array invariant is illustrated via numerical simulations in an ideal waveguide, and then demonstrated using experimental data from a ship of opportunity radiating broadband noise (200-900 Hz) and a vertical array in a shallow-water environment.

Extrapolating Green's functions using the waveguide invariant theory.

The broadband interference structure of sound propagation in a waveguide can be described by the waveguide invariant, ß, that manifests itself as striations in the frequency-range plane. At any given range (r), there is a striation pattern in frequency (ω), which is the Fourier transform of the multipath impulse response (or Green's function). Moving to a different range (r+Δr), the same pattern is retained but is either stretched or shrunken in ω in proportion to Δr, according to Δω/ω=ß(Δr/r). The waveguide invariant property allows a time-domain Green's function observed at one location, g(r,t), to be extrapolated to adjacent ranges with a simple analytic relation: g(r+Δr,t)≃g(r,α(t-Δr/c)), where α=1+ß(Δr/r) and c is the nominal sound speed of 1500 m/s. The relationship is verified in terms of range variation of the eigenray arrival times via simulations and by using real data from a ship of opportunity radiating broadband noise (200-900 Hz) in a shallow-water environment, where the steep-angle arrivals contributing to the acoustic field have ß≈0.92.

Multiple constraint matched field processing tolerant to array tilt mismatch.

A multiple constraint method (MCM) specifically designed to accommodate the uncertainty of array tilt is developed for matched field processing (MFP). Combining the MCM with the white noise gain constraint method results in a processor that is tolerant to both array tilt and environmental mismatch. Experimental results verify the robustness of the proposed MFP to localize and track a surface ship radiating broadband noise (200-500 Hz), using a 56-m long vertical array with tilt in approximately 100-m deep shallow water.

Localization of multiple ships using a vertical array in shallow water.

The blind deconvolution employs conventional plane-wave beamforming using an array, selects a well-resolved angle of arrival for beam steering to estimate the phase component of an unknown source waveform, and then extracts the Green's function between the source and the array. In this letter, the approach is extended to multiple-ship scenarios in which the multipath arrivals from one ship are masked by other ships, adopting the basic concept of successive interference cancellation. Once individual Green's functions are available, the array invariant method based on the beam-time migration can be subsequently applied to estimate each source range. Simultaneous localization of two ships radiating broadband noise (200-900 Hz) is demonstrated using a 16-element, 56-m long vertical array in approximately 100-m deep shallow water.

Remote acoustic illumination using time reversal and a surface ship.

Time-reversal (TR) transmission of the Green's function between a time-reversal mirror (TRM) and a probe source (PS) in an acoustic waveguide produces a spatio-temporal focus at the PS location. The TR focus then behaves as a virtual point source in the outbound direction with respect to the TRM. Further, a collection of adjacent TR focuses may constitute a virtual source array (VSA) that can serve as a remote platform, redirecting the focused field to a selected location beyond the VSA for which the Green's function is not available a priori. The practical limitation to the VSA implementation, however, is the requirement of a PS at multiple adjacent locations to obtain the Green's functions between TRM and VSA. Alternatively, this work proposes the use of a surface ship radiating broadband noise as a PS in conjunction with the waveguide invariant theory, instantly generating a horizontal VSA. The feasibility of remote acoustic illumination using a ship and a TRM is demonstrated using numerical simulations in shallow water.